Questions candidates found difficult on the H1 Biology 8876 (Nov 2023) papers — data handling, membranes, enzymes, DNA replication, meiosis, genetics, natural selection and climate.
Data handling — attributing an effect only to the variable that actually changed
Paper 1 Q8 — Parts of a phospholipidMembranes — the phosphate–glycerol head vs the fatty acid tails
Paper 1 Q9 — How enzymes lower activation energyEnzymes — lowering Ea means less energy needed to break bonds; complementary fit vs base pairing
Paper 1 Q12 — Comparing initial ratesKinetics — initial rate is the gradient at t = 0, read before curves level off
Paper 1 Q13 — DNA replication: polarity and condensationMolecular genetics — antiparallel 3′/5′ strands and condensation reactions
Paper 1 Q14 — Molecules vs nucleotides with light nitrogenSemi-conservative replication — count whole molecules, not individual nucleotides
Paper 1 Q16 — Errors in meiosisMeiosis — non-disjunction can put an extra copy of a chromosome into gametes
Paper 1 Q19 — X-linked genes in malesGenetics — males are hemizygous for X-linked genes (one allele only)
Paper 1 Q21 — What counts as a phenotypeGenetics — phenotype is any observable characteristic, by any method
Paper 1 Q26 — Who does natural selection benefit?Evolution — selection raises alleles that benefit individuals’ survival/reproduction, not ‘the population’
Paper 1 Q28 — Reducing greenhouse gases needs net absorptionEcology/climate — lowering atmospheric CO₂ requires net removal, not just lower emission
Paper 1 Q29 — Why you can’t average percentagesData handling — overall % change must be weighted by group sizes, not a mean of percentages
Original reconstructions inspired by the SEAB/Cambridge Examiner Report. Not actual examination questions.
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