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H1 Biology 8876 · Nov 2023BiologyPaper 1Commented

Paper 1 Q13 — DNA replication: polarity and condensation

Molecular genetics — antiparallel 3′/5′ strands and condensation reactions

What the examiners said

“Option B was selected by a significant proportion… These candidates had not considered the role of condensation reactions in DNA replication or the 3′ and 5′ polarity of DNA strands.”

Try the question

Which statement about DNA replication is correct?
Examiner report: “Candidates ignored condensation reactions and the antiparallel 3′/5′ polarity of the strands.”

Explore — build the new strand

Add nucleotides to a growing strand. Each join is a condensation reaction (water released) onto the 3′ end, running antiparallel to the template.

Two exam points made visible: covalent backbone bonds form by condensation (water out), and the new strand is antiparallel, extended only at the 3′ end.

Original reconstruction inspired by the misconceptions described in the Singapore-Cambridge GCE A-Level H1 Biology 8876 November 2023 Examiner Report. Not the actual examination question. For classroom exploration.

Made by lookang, using Claude Fable 5. More resources: iwant2study.org